CONTACTS
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| Phone: |
| Email: CWANG@MCG.EDU |
| Room: CA 4098 |
| Address: |
| Medical College of Georgia, |
| CBGM, 1120 15th Street, |
| CA4098, |
| Augusta, GA 30912 |
| MCG Faculty Page |
EDUCATION
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| Post-Doctoral, |
| University of Florida |
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| Visit. Scholar, |
| Austin Hospital, Austalia |
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| M.D., |
| Tongji Medical University, China |
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CONG-YI WANG:
ASSOCIATE PROFESSOR
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Research Areas
The research interests in Dr. Wang’s laboratory are to delineate the genetic basis for human diseases. The experimental approaches implicated in the research projects include functional genomics, proteomics, immunology and generation of animal models. We are interested in both complex diseases such as type 1 diabetes, and Mendelian diseases such as Urofacial (Ochoa) Syndrome (UFS). Our goal is to dissect the genetic defects and molecular mechanisms by which lead to these disorders.
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postdoc/research scientist position in Dr. Wang's Lab (Urofacial Syndrome)
Successful candidate must have a Ph.D. degree in biochemistry/cell biology, and will conduct functional studies of the UFS gene responsible for the Urofacial (Ochoa) Syndrome. The UFS gene has been found to play a pivotal role in the regulation of facial muscle contractility and smooth muscle contractility in the urinary bladder and urethral sphincter. UFS encoded protein is a transmembrane enzyme probably implicated in the degradation of neuronal signaling molecules. The candidate will need to characterize the potential substrates for this particular enzyme, and then demonstrate the exact molecular mechanisms through which contribute to the human disease phenotype in animal models. The candidate should have experience for assays of muscle contractility, electrical field stimulation and other related physiological assays for urinary bladder. Individual with research background in signal transduction is preferred. Please send an enhanced C.V. to cwang@mcg.edu or visit our website for more information.
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Research Funding Resources
Research activities in Dr. Wang's lab are supported by grants from the National Institute of Health (DK074957-01), the Juvenile Diabetes Research Foundation International (1-2004-235, 1-2007-181 and 1-2007-192), the American Diabetes Association (1-05JF-47) and the Medical College of Georgia (RI00329 and HI00105G).
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patents
1). Activators of Cyclin-Dependent Kinases (ACDK). US and International Patent PCT/US02/23147
2). SUMO4 gene and methods of use for type 1 diabetes. US and International Patent: US 7,173,119 B2
3). Ancient Conserved Domain Proteins (ACDP), a family of divalent ion transporters in mammalian cells. US and International Patent: 18-05
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Characterization of the Urofacial Syndrome Gene
The goal of this project is to perform positional cloning of the urofacial syndrome gene, an autosomal recessive disorder.
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Hmgb1, an innate-mediator in autoimmunity
Hmgb1 can be passively released from necrotic cells; it can also be actively released by activated macrophages and dendritic cells. Our focus for this project is to understand how Hmgb1 functions as an endogenous signal involved in the initiation and progresion of autoimmunity.
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Sumoylation in the pathogenesis of type 1 diabetes
We focus on the functional significance of sumoylation in the pathogenesis of type 1 diabetes in two aspects: 1). The role of sumoylation in immune cell (e.g., dendritic cells) development and functional activity during autoimmunity; 2). The impact of sumoylation on autoimmune-mediated beta cell death in type 1 diabetes.
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Sumoylation regulates endothelial dysfunction and nephropathy
The objective of this project is to demonstrate the role of SUMO1 sumoylation in the regulation of endothelial dysfunction and kidney damage during diabetic hyperglycemia.
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DNA methylome-encoded information modulates T1D susceptibility
This project is designed to demonstrate the role of epigenome-encoded information in the pathogenesis of type 1 diabetes.
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Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.
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Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY
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Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA.
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Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis.
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Guo D, Ling J, Wang MH, She JX, Gu J, Wang CY
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Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA. jgu@dental.ufl.edu.
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SUMO wrestling with type 1 diabetes.
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Li M, Guo D, Isales CM, Eizirik DL, Atkinson M, She JX, Wang CY
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Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA.
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A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.
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Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY
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Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, Georgia 30912, USA.
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Intergeneration CAG expansion and contraction in a Chinese HD family.
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Tang Y, Wang Y, Yang P, Liu Y, Wang B, Podolsky R, McIndoe R, Wang CY
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Department of Cell Biology and Genetics, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
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Molecular cloning and characterization of the mouse Acdp gene family.
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Wang CY, Yang P, Shi JD, Purohit S, Guo D, An H, Gu JG, Ling J, Dong Z, She JX
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Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, PV6B108, Augusta, GA 30912, USA. cwang@mail.mcg.edu
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High resolution mapping and mutation analyses of candidate genes in the urofacial syndrome (UFS) critical region.
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Wang CY, Davoodi-Semiromi A, Shi JD, Yang P, Huang YQ, Agundez JA, Moran JM, Ochoa B, Hawkins-Lee B, She JX
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Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA.
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Extracellular Hmgb1 Functions as an Innate Immune-Mediator Implicated in Murine Cardiac Allograft Acute Rejection.
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Huang Y, Yin H, Han J, Huang B, Xu J, Zheng F, Tan Z, Fang M, Rui L, Chen D, Wang S, Zheng X, Wang CY, Gong F
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Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
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Extracellular HMGB1 acts as an innate immune-mediator to enhance autoimmune progression and diabetes onset in NOD mice.
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Han J, Zhong J, Wei W, Wang Y, Huang Y, Yang P, Purohit S, Dong Z, Wang MH, She JX, Gong F, Stern DM, Wang CY
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Center for Biotechnology and Genomic Medicine, Department of Pathology, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA.
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Dietary and Lifestyle Changes Associated with High Prevalence of Hyperuricemia and Gout in the Shandong Coastal Cities of Eastern China.
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Miao Z, Li C, Chen Y, Zhao S, Wang Y, Wang Z, Chen X, Xu F, Wang F, Sun R, Hu J, Song W, Yan S, Wang CY
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From the Department of Endocrinology, Medical School Hospital of Qingdao University, Qingdao, China; and the Center for Biotechnology and Genomic Medicine and Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA.
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A stress-dependent SUMO4 sumoylation of its substrate proteins.
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Wei W, Yang P, Pang J, Zhang S, Wang Y, Wang MH, Dong Z, She JX, Wang CY
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Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA.
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